News from Paris Lab
News from Paris Lab
New paper from the Paris lab published in the Journal of Urology.
This paper reports on an NIH R01 funded study to validate the GEMCaP biomarker set. GEMCaP (Genomic Evaluators of Metastatic Prostate Cancer), discovered as part of an NIH funded prostate cancer SPORE project, is a suite of DNA-based biomarkers associated with prostate cancer recurrence and metastasis. In the current study, a high GEMCaP score was associated with biochemical recurrence in two external cohorts (Cleveland Clinic and Rochester). This remained true after adjusting for clinical and pathologic factors. The GEMCaP biomarker could be an efficient and effective clinical risk assessment tool to identify prostate cancer patients for early adjuvant therapy. Great job Drs. Hao Nguyen, Chris Welty and Karla Lindquist!
The link to the online version of the paper is here:
New paper from the Paris Lab published in Molecular Cancer Research:
This was a multi-discipline collaboration with Drs. Rahul Aggarwal (Med Onc-GU)and Mike Evans (Radiology) at UCSF. The online version of the paper, published in June, addresses if Ga-citrate can be used to detect prostate cancer tumors overexpressing MYC. Our laboratory explored whether MYC could be assessed in the circulation of patients with advanced prostate cancer (mCRPC) using a simple blood draw. The Ga-transferrin imaging results were compared to the cell free (cf) DNA results obtained from the same patients. cfDNA seems to be a viable way to non-invasively evaluate patients for their MYC tumor status. Down the line, these could be used as fairly non-invasive biomarkers to determine if a patient is a good candidate for a drug that targets this pathway.
The link to the online version of the paper:
Hao Nguyen, MD, PhD abstract at AUA 2017
Hao Nguyen, MD, PhD, Assistant Professor, Department of Urology presented an abstract to the AUA meeting and it was selected as a talk in the Biomarker session at AUA 2017 in Boston. The topic was: Validation of GEMCaP as a DNA based biomarker to predict prostate cancer recurrence after radical prostatectomy.
Dr. Lindquist, postdoctoral fellow, wins award
Lab member, Karla Lindquist submitted an abstract for a meeting, Cancer Metastasis through the Lymphovascular System: Biology & Treatment, 7th International Symposium, held last week in San Francisco. Her abstract was selected not only as a poster but also as a talk! And, she won a best talk award at the meeting!
New paper published in BMC Cancer.
This paper reports on the ability to detect PD-L1 expression successfully on circulating tumor cells of patients with muscle-invasive and metastatic bladder cancer consistently. Genomic analysis of these CTCs support their tumor origin. This demonstrates the ability to detect PD-L1 on tumor cells through a minimally invasive process and holds the potential to guide checkpoint inhibitor immune therapies established to have activity in this patient population.
New paper from the lab published in Cancer Letters!
The Cancer Letters paper published by lab member Gayatri Premasekharan reports on an an improved CTC isolation scheme that increases the purity of circulating tumor cells (CTCs) ...
DoD Health Disparity Award
Dr. Paris was awarded a DoD Health Disparity Award with Drs. Al Levin and Ben Rybicki at Henry Ford.
The October 2014 issue of The American Journal of Pathology showcased research from the Paris lab and collaborators from the National Institute of Health.
Pediatric Glioma collaboration
The 2013 Annual Prostate Cancer Retreat bestowed two poster awards to Paris Lab members.