Leslee L. Subak, MD
Leslee L. Subak, MD
Leslee Subak, MD, who joined the urology faculty in 2007, holds appointments in three UCSF School of Medicine departments. After earning her MD at Stanford University, she served as administrative chief resident in the Department of Obstetrics, Gynecology & Reproductive Sciences at UCSF, subsequently completing concurrent fellowships at UCSF in epidemiology and clinical research, and in urogynecology and pelvic surgery. She has served on the UCSF faculty since 1997. Dr. Subak is the Co-Director of the UCSF Women’s Health Clinical Research Center, Chief of Gynecology at the San Francisco Veterans Affairs Medical Center (SFVAMC), and co-directs both the SFVAMC Advanced Fellowship in Women’s Health Clinical Research and the Women’s Reproductive Health Research Career Development Program. She has been on the 1st through 5th International Consultations on Incontinence Committee on the Socio-Economic Impact of Urinary Incontinence sponsored by the World Health Organization and International Continence Society. She is principal investigator on several federally funded research projects evaluating the treatments of urinary incontinence in women, with particular emphasis on the effects of weight reduction on improving symptoms in obese women, effect of yoga on incontinence, treatment of lower urinary tract symptoms in elderly women, and the economics and cost-effectiveness of interventions for incontinence.
Dr. Subak’s clinical interests are in treatment of dysfunction in female bladder and pelvic floor, as well as urinary incontinence.
Dr. Subak is co-principal investigator of the Biostatistics and Data Management Core in the UCSF Specialized Center of Research on Lower Urinary Tract Function in Women (SCOR). The SCORE funds a collaborative group of basic and clinical investigators doing translational research on the female urethra, bladder and pelvic floor, as well as urinary incontinence. This multidisciplinary group includes members of the UCSF Departments of Epidemiology & Biostatistics; Family Practice; Obstetrics, Gynecology & Reproductive Sciences; and Urology. The SCOR provides an efficient mechanism for development and completion of collaborative, multi-institutional, multi-disciplinary translational research.
As an internationally recognized leader in the economic analyses of incontinence, Dr. Subak has been a member of the Socio-Economic Impact of Urinary Incontinence Committee for the International Consultation on Incontinence sponsored by the International Continence Society and the World Health Organization. She has been the principal investigator on several NIDDK funded studies to evaluate costs, utilities and cost-effectiveness of treatments for incontinence and of weight loss.
My research focuses on the association of weight and urinary incontinence (UI) in women and clinical trials to test strategies to improve outcomes in women’s genitourinary health. Since obesity is a potentially modifiable risk factor for UI, I have done a series of studies showing that weight reduction is an effective treatment option for UI. We observed a significant improvement in UI following low calorie liquid diet programs, behavioral weight loss, and bariatric surgery. Our multi-disciplinary team investigates the epidemiology of female lower urinary tract and pelvic floor disorders to identify risk factors, particularly those that are modifiable, for UI. We investigate prevalence of and risk factors for UI, pelvic organ prolapse, sexual dysfunction, and fecal incontinence and the association of childhood and adult lower urinary tract symptoms and differences in prevalence of UI by race/ethnicity. With several interdisciplinary colleagues, we have developed and tested in randomized trials novel treatments for UI, including weight loss, yoga and slow-paced respiration. Our current focus is on interventions for primary and secodary prevention of UI in women.
UCSF Women's Health Clinic Research Center
550 16th Street, 6th floor
San Francisco, CA 94143