Chesner Lab

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Our research centers on uncovering molecular mechanisms that regulate prostate cancer progression and treatment response. Our work examines hormone signaling, immune regulation in tumors, and utilizes genome-wide functional genomics approaches such as CRISPR screening to identify novel therapeutic strategies. The Chesner lab is particularly interested in how hormone receptor activity affects antigen presentation and immune recognition in prostate cancer, as well as identifying synthetic lethal vulnerabilities in genetically defined tumors, including ATM-deficient prostate cancers.