
Donna Peehl, PhD
Education
Biography
Dr. Peehl’s current studies focus on developing novel therapeutics for prostate and kidney cancer. In collaboration with investigators at UCSF and Stanford, she is testing novel inhibitors of the tyrosine kinase AXL and of the scaffold protein, IQGAP, for their anti-cancer activity in her patient-derived models of kidney cancer. Another project uses tissue slice cultures to investigate cancer-associated glycosylation as a novel immunotherapy target. Under the auspices of a new NIH U01 grant, Dr. Peehl is collaborating with Dr. John Kurhanewicz and others at UCSF to compare metabolism of four types of kidney cancer preclinical models by hyperpolarized molecular imaging.
Dr. Peehl has been the recipient of numerous grants from the NIH and Department of Defense (DoD) Prostate Cancer Research Program, and has received awards from the Prostate Cancer Foundation (formerly CaP CURE) to support her research. She has served as chair or scientist reviewer for many NIH and grant review panels and has reviewed or served on the editorial board for a large number of scientific journals. Her peer-reviews include over 200 articles and publications.
Expertise:
Urology
Specialty:
Prostate cancer, kidney cancer, molecular and cellular biology
Professional Interests:
Patient-derived xenografts, tissue slice cultures, primary cultures, spheroid cultures, preclinical drug testing, biomarkers, metabolism, cancer biology, translational science
Research Interests
September 7, 2020 - August 31, 2025 - Co-Clinical Quantitative Imaging of Small Cell Neuroendocrine Prostate Cancer Using Hyperpolarized 13C MRI , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U24CA253377
September 1, 2017 - July 31, 2022 - Metabolic imaging comparisons of patient-derived models of renal cell carcinoma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA217456
August 28, 2006 - July 31, 2013 - A Serum Marker for Aggressive Prostate Cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA121460
September 30, 1993 - August 31, 1996 - GROWTH FACTORS IN THE PROSTATE: AN IN VITRO MODEL , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK047551
September 7, 2020 - August 31, 2025 - Co-Clinical Quantitative Imaging of Small Cell Neuroendocrine Prostate Cancer Using Hyperpolarized 13C MRI , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U24CA253377
September 1, 2017 - July 31, 2022 - Metabolic imaging comparisons of patient-derived models of renal cell carcinoma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA217456
August 28, 2006 - July 31, 2013 - A Serum Marker for Aggressive Prostate Cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA121460
September 30, 1993 - August 31, 1996 - GROWTH FACTORS IN THE PROSTATE: AN IN VITRO MODEL , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK047551
Publications
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Publication Year2025
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Publication Year2023