James F. Smith, MD, MS

James F. Smith, MD, MS

James F. Smith, MD, MS

Professor and Director, Male Reproductive Health


BA, 1996, Molecular Biology, University of California, Berkeley
MS, 2000, Health & Medical Sciences, Joint Medical Program, School of Public Health, University of California, Berkeley
MD, 2002, Medicine, University of California, San Francisco
Certificate, 2008, Advanced Training in Clinical Research, Department of Epidemiology & Biostatistics, University of California, San Francisco
Surgical Intern, University of Utah, Salt Lake City, UT 2002-2003
Urology Resident, University of Utah, Salt Lake City, UT 2003-2006
Chief Urology Resident, University of Utah, Salt Lake City, UT 2006-2007
Andrology Fellow, Department of Urology, University of California, San Francisco 2007-2009


James Smith, MD, MS received his undergraduate training from the University of California, Berkeley, where he obtained a degree in molecular biology with high honors. He then enrolled in the University of California's Joint Medical Program, a partnership between Berkeley's School of Public Health and San Francisco's School of Medicine where he earned a master's degree in health and medical science in 2000 and a medical degree in 2002. Smith completed his general surgery and urology training at the University of Utah in Salt Lake City, returning to the University of California, San Francisco as an Andrology Fellow in 2007 for advanced clinical and clinical research training in male reproductive and sexual health under the guidance of Tom Lue, MD and Ira Sharlip, MD.  In 2009, he was awarded a K12 MRHR (Male Reproductive Health Research) grant to continue his investigation into male reproductive health.

Clinical Interests

As Director of Male Reproductive Health at UCSF, Smith directs the multidisciplinary team providing male fertility preservation counseling and treatment; evaluates and treats men with male reproductive health problems, desire for vasectomy, low testosterone, and erectile dysfunction. He specializes in the use of minimally invasive vasectomy, microsurgical vasectomy reversal, advanced sperm retrieval techniques, microsurgical varicocele repair, and microsurgical spermatic cord denervation. Smith is an active member of the American Urological Association, the American Society for Reproductive Medicine, Society of Reproductive Surgeons, Society for the Study of Male Reproduction, Society for Male Reproduction and Urology, American Society of Andrology, and the Sexual Medicine Society of North America.

Research Interests

Smith’s NIH and Department of Urology funded research program centers on his desire to help men and boys with cancer become fathers after surviving cancer treatment. Smith’s research is highly collaborative and studies a range of problems focused on achieving this goal. His long-term objective is to develop a nationally and internationally recognized multidisciplinary cancer and reproduction program. This program is comprised of: A. clinical fertility preservation for adults and children; B. basic science investigation of sperm physiology, sperm stem cells, and semen physiology; C. translational research focused on fertility preservation and restoration; D. clinical research into the reproductive effects of cancer therapy; and E. health services research exploring costs of reproductive care, disparities in access to care, and ethical implications of fertility preservation therapy for children.

Patient Contact

For Urology patients contact:

Parnassus Physical Address:
400 Parnassus Avenue, Suite 610
San Francisco CA 94143

415.353.2200  (Phone)

415.353.2641 (Fax)



Fertility Preservation Contact Information

All cancer patients evaluated within 24 to 48 hours by calling the fertility preservation hotline at:  415.353.7475

Academic Contact

415.885.3694  (Phone)
415.885.7443  (Fax)

Department of Urology
San Francisco, CA 94143-1695