Matthew R. Cooperberg, MD, MPH
Education
- BA, 1995, English, Dartmouth College, Hanover, NH
- MPH, 2000, Yale University School of Epidemiology and Public Health, New Haven, CT
- MD, 2000, Medicine, Yale University School of Medicine, New Haven, CT
Biography
Matthew Cooperberg, MD, MPH received his undergraduate training from Dartmouth College, where he earned a degree in English with high honors. He then enrolled in Yale University's MD, MPH program, concurrently earning an MPH with a concentration in Health Policy from the School of Epidemiology and Public Health, and a MD from the School of Medicine. He completed his General Surgery and Urology training at the University of California, San Francisco, and subsequently continued at UCSF to complete a fellowship in Urologic Oncology under the guidance of Peter Carroll, MD, MPH. In 2009, Dr. Cooperberg was recruited to join the faculty at UCSF and the San Francisco Veterans Affairs Medical Center. Specializing in urologic cancer care, he is part of the multidisciplinary urologic oncology team of the UCSF Helen Diller Family Comprehensive Cancer Center, located primarily at the Mission Bay campus. He also maintains privileges at San Francisco General Hospital. In 2013, Cooperberg received the first Helen Diller Family Chair in Urology and a secondary appointment in the Department of Epidemiology and Biostatistics. In 2015 he won the American Urological Association Gold Cystoscope Award, given annually to one urologist for contributions to the field in the first 10 years of practice, and was also named Young Urologist of the Year. He was named professor in 2018.
Clinical Interests
Dr. Cooperberg's clinical interests include the early detection, diagnosis, and management of genitourinary malignancy, and using minimally invasive techniques to treat benign and malignant diseases. He performs robotic, laparoscopic, endoscopic, and percutaneous surgeries, and is interested in incorporating promising new technologies into his practice. He is particularly interested in risk-stratifying prostate, renal, and other tumors, and matching treatments appropriately to those patients most likely to benefit, using novel imaging tests and biomarkers together with clinical information. Dr. Cooperberg is a Fellow of the American College of Surgeons, and a member of the American Urological Association (AUA) and the Society for Urologic Oncology. In 2012. Dr. Cooperberg co-wrote a proposal to establish a national urology registry. From this proposal developed the AUA Quality (AQUA) Registry, a national database tracking practice patterns, quality of care, and both clinical and patient-reported outcomes for patients across the U.S. with prostate cancer and other urologic conditions. Dr. Cooperberg continues in a senior leadership role with the project.
Research Interests
Dr. Cooperberg has an extensive research background in prostate cancer clinical and outcomes research, with nearly 600 peer-reviewed publications spanning early detection, risk assessment, biomarker validation, comparative effectiveness, health-related quality-of-life outcomes, and spatial biology. His work has focused on creating tools and evidence that improve real-world decision-making and help match treatments to individual patients. He led the development and validation of the UCSF Cancer of the Prostate Risk Assessment (CAPRA) pre- and post-operative scores, which have now been independently validated in more than 20,000 patients across multiple cohorts. He also authored the proposal for the American Urological Association’s national AUA Quality (AQUA) Registry and served as Senior Physician Advisor during its first decade, helping to build the data infrastructure for measuring practice patterns, quality, and outcomes in urologic care. He has served as Associate Editor of European Urology, the Journal of the National Cancer Institute, and other publications. In 2015 received the AUA Gold Cystoscope Award for contributions to the field during my first decade in practice. He also serve as Medical Director of the prostate cancer task force for SF-CAN, a citywide initiative to reduce cancer mortality through coordinated population-level interventions. His current research program includes R01-funded projects in biomarker development and validation, and I serve as co-PI of the Prostate Project within UCSF’s U54 Outcomes SPORE, with the goal of understanding biology and outcomes through combined analysis of social and structural determinants of health, pathology artificial intelligence, and spatial multi-omics.
Videos
This series of videos, Dr. Matt Cooperberg provides an overview of clinically localized prostate cancer, intended primarily for newly diagnosed patients and their families, covering risk stratification, active surveillance, surgery (prostatectomy), radiation therapy, and focal therapy.
Publications
View All Research PublicationsPatient Contact
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